Women should be advised about this side effect when starting an AI, and encouraged to report these symptoms to the healthcare team. Carpal tunnel syndrome is a common diagnosis in women with AI-related joint symptoms. The cause is not known; people who tend to smoke may have lower pain thresholds than those who don’t, or the smoking may somehow lower the body’s pain threshold. Small studies have found a benefit to acupuncture and exercise. Treatment is different for each stage. They may be able to offer ways of improving your symptoms. A joint is where 2 bones in your body connect. Studies have found joint symptoms most often develop within the first 3 months on therapy, though some cases continue to develop after 3 months. Swallow the tablet with a drink of water. Bisphosphonates, medicines used to treat osteoporosis, may cause bone or joint pain. Began letrozole, experienced hot flashes/insomnia. Additional pain relieving medications, including acetaminophen and opioids, can be added for those patients who do not get relief with an anti-inflammatory alone or for those who cannot tolerate the anti-inflammatory medications. Toggle navigation. Copyright © 2021 IBM Watson Health. Prior to switching, it may be beneficial to stop therapy for 6 to 8 weeks to be sure that the AI is the cause of the symptoms. ... “ Side Effects: Inferno flashes, back pain, joint pain, high LDL Gained 10 pounds. Joint pain is a very common problem with many possible causes, but it's usually a result of injury or arthritis. However, for some people they may cause distress and disrupt everyday life. Joint pain often occurs in … There may also be an increased risk for those with pre-existing joint symptoms, such as rheumatoid arthritis. Along with its needed effects, letrozole may cause some unwanted effects. Joint pain and stiffness are common side effects of the aromatase inhibitors (doctors call these pains “arthralgias”). Drug information provided by: IBM Micromedex. First and foremost, patients should talk with their oncology team if they develop joint symptoms. Breast Cancer Res Treat 111:365-72, 2008, Henry NL, Giles JT, Stearns V: Aromatase inhibitor-associated musculoskeletal symptoms: etiology and strategies for management. Call your doctor for medical advice about side effects. As a former therapist, I switched to exercise in pool as I could no longer tolerate joint pain with land based exercise. It limits your range of motion and makes it so much harder for your muscles to take the load off your joints and, in time, it can cause misalignment of the spine which eventually leads to … As I entered 1.5 year mark taking letrozole I began to have joint pain, deep aching and less strength in hips/knees. Gentle stretching and exercise may also be helpful in reducing symptoms. Mayo Clinic does not endorse companies or products. Breast pain is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for < 1 month. My doc said that letrozole affects the bursa in your joints, causing an inflammatory type response. Though it is present in both women and men, it is more prominent in women as it plays a key role in regulating menstrual cycles and preparation for … Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. So I take Aleve when it acts up. I noticed my joints felt like I’ve aged 10 years in the 2 1/2 since diagnosis. Hot flashes, hair loss, joint/bone/muscle pain, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. There has been recent interest in the possibility that vitamin D supplementation may help to decrease AI-related arthralgia, although this has not been proven in clinical trials. The drop in estrogen causes cytokines (proteins released by the body’s cells) to be released in high levels, which may hasten bone loss and aging, leading to pain. While there are no studies to confirm the effectiveness of changing to another drug, some practitioners will switch to another AI or tamoxifen when symptoms are unmanageable and may lead to the patient stopping therapy altogether. Cancer 115:3631-9, 2009, Muslimani AA, Spiro TP, Chaudhry AA, et al: Aromatase inhibitor-related musculoskeletal symptoms: is preventing osteoporosis the key to eliminating these symptoms? Hello Yvonne I am taking letrozole and have been for four and a half months in order to shrink the tumour before surgery. Up to 50% of women taking an aromatase inhibitor have joint pain or stiffness. Along with its needed effects, a medicine may cause some unwanted effects. You may report side effects to the FDA at 1-800-FDA-1088. All content © 2021 Trustees of the University of Pennsylvania. If you notice any other effects, check with your healthcare professional. When the problem becomes chronic, patients may end up with deformity and permanent damage to the articulation, as well as joint stiffness. I started taking Arimidex 13 months ago. Researchers continue to seek ways to identify women at highest risk for developing this side effect and to find effective therapies to treat it. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Pain is usually located in more than one articulation, and during breaks, the patient may be asymptomatic or still display milder pain symptoms. Oncology (Williston Park) 22:1416, 1424, 2008, Henry NL, Giles JT, Ang D, et al: Prospective characterization of musculoskeletal symptoms in early stage breast cancer patients treated with aromatase inhibitors. Wonder what it does exactly to cause it. The actual cause of AI-related joint symptoms is not well understood. Medications, Health History and Cancer Risk, Sexual History & Human Papillomavirus (HPV), Insurance, Legal, Employment & Financial Concerns, Aprepitant Oral; Fosaprepitant IV (Emend®); Aprepitant IV (Cinvanti®), Compazine®- Oral Tablet / IM / IV / Suppository, Diphenhydramine Hydrochloride- Oral / IV / IM / Topical, Emend®; Fosaprepitant IV (Emend®); Aprepitant IV (Cinvanti®), Oxycodone Sustained/Extended Release Pill, Prochlorperazine- Oral Tablet / IM / IV / Suppository, Promethazine hydrochloride Oral / IV / Suppository / IM, Rituximab and Hyaluronidase Human Injection, Gestational Trophoblastic Disease and Choriocarcinoma, Leukemia-- Acute Lymphocytic Leukemia (ALL), Leukemia-- Acute Myelogenous Leukemia (AML), Cancer, COVID-19, and Competing Threats to Indigenous Health, Breast Cancer Prevention (PDQ®) (Health professionals), Breast Cancer Treatment (Adult) (PDQ®) (Health professionals), Oral Complications of Chemotherapy and Head/Neck Radiation (PDQ®) (Health professionals), Cancer Pain (PDQ®) (Health professionals), Acupuncture (PDQ®) (Health professionals). If there was no previous history of arthritis prior to taking Femara or Letrozole, then joint pain as a side effect will eventually go away after intake. Take one 2.5 mg letrozole tablet every day. Thanks Mikki. Progesterone is a hormone naturally produced in the body. Acupuncture was shown to reduce pain from joint symptoms and improve functioning and well-being. Oncology (Williston Park) 22:1401-8, 2008, Mao JJ, Bruner DW, Stricker C, et al: Feasibility trial of electroacupuncture for aromatase inhibitor--related arthralgia in breast cancer survivors. My sister's breast cancer was in final stages, even in her one lung and yet 2 yrs later she is still here and feeling well. These can occur in more than 1 in 10 women who take letrozole. Pain in the joints, also called arthralgia, is a possible side effect of cancer and its treatment. One common theory is that the rapid drop in estrogen levels may be responsible for joint pain for two reasons: This drop may actually lower the pain threshold, allowing the brain to better "detect" joint symptoms that already exist. Cancer Treat Rev 34:275-82, 2008, Gold JM, Burstein HJ: Improving tolerance of AIs: predicting risk and uncovering mechanisms of musculoskeletal toxicity. I empathise with you as I am having awful joint pain too, particularly in my legs,knees and feet. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This drop may actually lower the pain threshold, allowing the brain to better "detect" joint symptoms that already exist. I also have about ten or more hot flashes per day with foggy memory and joint pain at night so find it difficult to sleep. Common bisphosphonates are Fosamax (chemical name: alendronate sodium), Actonel (chemical name: risedronate), and Boniva (chemical name: ibandronate). Joint pain with swelling is the most common non-GI complication of IBD. Side Effects. Integr Cancer Ther 8:123-9, 2009, Mao JJ, Stricker C, Bruner D, et al: Patterns and risk factors associated with aromatase inhibitor-related arthralgia among breast cancer survivors. Although not all of these side effects may occur, if they do occur they may need medical attention. It would be helpful for healthcare providers to have a way of predicting who is at greatest risk for developing AI-related joint symptoms. This content does not have an Arabic version. Discover information about different types of cancer, Learn about cancer, diagnosis, treatment, coping & survivorship, Find resources & tools for oncology healthcare professionals. Druginformer Identified Side Effects: Fatigue, Vulvovaginal dryness, Pain, Joint swelling, Arthritis, Alopecia, Loss of libido. These joint symptoms, often called arthralgias, can interfere with quality of life and are often the cause of a woman stopping therapy early. Although not all of these side effects may occur, if they do occur they may need medical attention. Bone pain, joint pain or muscle ache; Hot flushes can sometimes occur If this occurs, take your tablets at bedtime. I have been on it for 5 years and will come off it and move to Tamoxifen in October. The phase IV clinical study is created by eHealthMe based on reports of 24,728 people who have side effects when taking Letrozole from the FDA, and is … Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Therefore, a medication that decreases this swelling, such as non-steroidal anti-inflammatory drugs (NSAIDS, such as ibuprofen) or a coxib (such as celecoxib, or Celebrex), may help with pain relief. One common theory is that the rapid drop in estrogen levels may be responsible for joint pain for two reasons: Unfortunately, a poor understanding of the cause makes it difficult to prevent this side effect. Research continues to identify factors that could help better predict each woman's risk. Other diagnoses include osteoarthritis, tendonitis and bursitis. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Avoid alcohol as it may make you feel more tired and drowsy. Unfortunately, studies have not found consistent predictors. Hi! Bone fracture 2. breast pain 3. chest pain 4. chills, fever, or flu-like symptoms 5. mental depression 6. swelling of the feet or lower legs She didn't get sick from chemo and only side effect now is the bone pain. Joint pain can occur in the hands, feet, knees, hips, shoulders, lower back, spine, and other joint areas. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The reason is not understood, but it does appear smokers suffer more pain than nonsmokers, in the back, legs, knees, and joints. In older people, joint pain that gets steadily worse is usually a sign of osteoarthritis.. A significant component of the joint symptoms experienced with AIs is swelling of the joints. Sometimes it is used to treat breast cancer in men.. Letrozole may be used: before surgery, to try to reduce the size of the cancer and avoid a mastectomy (removal of the breast) This site complies with the HONcode standard for trustworthy health information: verify here. Joint pain is found among people who take Letrozole, especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months. I’ve found that trying to as active as I can on the good days seems to help my joint pain … Symptoms typically affect the fingers, hands, wrists, elbows, shoulders, knees and ankles. After one year, no hot flashes but sleep disruption. All rights reserved. While AIs are an effective therapy in reducing the risk of breast cancer recurrence, they increase the risk of developing osteoporosis and commonly cause joint (or muscle) aches and pains. Receive the latest resources and updates in your inbox. Medications - certain medications, as a side effect, can cause joint pain. Annals of Oncology. This content does not have an English version. Tiredness and lack of energy may occur If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. The joint pain is usually relieved when the medications are stopped. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Clin Breast Cancer 9:34-8, 2009, Niravath, P. Aromatase inhibitor-induced arthralgia: a review. An enzyme called aromatase is responsible for this conversion. Most women experiencing bone and joint pain reported having stiffness and pain upon awakening in their hands, hips, back, knees, feet, and shoulders that made it difficult to perform daily activities and work-related tasks. 1. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online, pain in the chest, groin, or legs, especially the calves, severe and sudden, unexplained troubled breathing, sudden, severe weakness or numbness in the arm or leg, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, sores, ulcers, or white spots on the lips or in the mouth, hot flashes (sudden sweating and feeling of warmth), spinning or whirling sensation causing loss of balance, Bad, unusual, or unpleasant (after) taste and thirst. Other side effects from this medicine include hot flashes, hair loss, tiredness, unusual sweating, nausea, diarrhea, dizziness, and trouble sleeping may occur. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. The management of joint symptoms is of utmost importance to helping patients complete their prescribed therapy in full. Your specialist may suggest changing to a different aromatase inhibitor such as anastrozole or exemestane, or another hormone treatment, as some women get on better with a differe… Portions of this document last updated: Feb. 01, 2020. Some pain medications, such as Feldene (chemical name: piroxicam) also can cause bone or joint pain. Arthritis isn't the only cause of joint pain. Ulcerative colitis is a type of inflammatory bowel disease (IBD). Infections in the joint ; Other inflammatory conditions, such as gout (a collection of uric acid crystal deposits in the joint), or lupus ; Symptoms of Arthralgias: Found at: http://annonc.oxfordjournals.org/content/early/2013/03/06/annonc.mdt037.full.html. Coleman RE, Bolten WW, Lansdown M, et al: Aromatase inhibitor-induced arthralgia: clinical experience and treatment recommendations. On the flip side, taking tamoxifen before an AI may reduce the likelihood of developing joint symptoms. All rights reserved. Now, the other side effects of hair loss, joint pain, fatigue and still, insomnia have made me decide a year later to try mornings again. Aromatase inhibitors (AIs) are a common therapy for post-menopausal women with hormone positive breast cancer. View detailed reports from patients taking Letrozole who experienced back pain. My joint pain was a challenge for about 4 years, but this year is a major improvement. Some studies have suggested that calcium and bisphosphonate therapy (used to prevent/treat osteoporosis) may also prevent AI-related joint symptoms. However, these medications are not without side effects of their own, so each patient should discuss his/her health history with the team before starting these medications. It is important to communicate with your team if your side effects are making it difficult for you to take your medications as directed. Bone fracture; breast pain; chest pain After menopause, estrogen is mainly produced by converting androgens (sex hormones produced by the adrenal glands) into estrogens, which occurs in fat cells (as opposed to in the ovaries before menopause). Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Hormonal imbalances, including low testosterone, can contribute to aches and pains in your joints. For many people, side effects improve within the first few months of starting the treatment. In turn, the goal is to treat the symptoms to allow women to have good quality of life while completing their prescribed therapy in full. There's two main differences: it doesn't have anti-estrogenic side effects like clomid; and although studies have proven letrozole is an effective fertility drug it hasn't been approved by the FDA yet for fertility use, thus isn't covered by insurance (beware it's very expensive). The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. The following are all of the major potential Letrozole side effects associated with Estrogen reduction. COVID-19: What you need to know Vaccine updates, safe care and … If you have any side effects, whether they’re listed here or not, talk to your GP or treatment team. The Femara is an excellent drug. Some studies have shown that having received prior chemotherapy, prior hormone replacement therapy, prior taxane chemotherapy (paclitaxel, taxotere) and having had their last menstrual period within 5 years may predict increased risk. 2013. These side effects may go away during treatment as your body adjusts to the medicine. Joint and bone pain: Anecdotally, bone and joint pain has been a commonly reported effect of Letrozole, and in fact is a more commonly reported effect resulting from Letrozole than any of … Doctors will prescribe either clomid or letrozole to assist with ovulation. It may affect just 1 joint or many. I'm sure Letrozole/Femara is the cause of the joint pain. To derive the full benefit from AI therapy, it is important to take the medication daily, for as long as it is prescribed. Find out why and what treatments are available. The phase IV clinical study is created by eHealthMe based on reports of 24,728 people who have side effects when taking Letrozole from the FDA, and is … swelling and tenderness or pain along a vein – these can be signs of a blood clot muscle weakness, pain or swelling in the joints or tendons in your ankle, calf or legs, shoulder or arms a high temperature or chills – these can be signs of an infection Less common but more severe side effects of these medicines include heart problems, osteoporosis, and broken bones. Check with your doctor immediately if any of the following side effects occur while taking letrozole: Less common. At first I took it at night, but when the side effect of insomnia began, I switched to mornings. All rights reserved. PRECAUTIONS: Before taking letrozole, tell your doctor or pharmacist if you are allergic to it; or to anastrozole; or if you have any other allergies.This product may contain inactive ingredients, which can cause allergic reactions or other problems. The oncology team is there to support each patient to complete their prescribed therapy and will help identify ways to manage this side effect. In studies of AI-related joint symptoms, anywhere from 20-50% of women on therapy reported the side effect. Joint pain: Symptom — Overview covers definition, possible causes of joint pain. Letrozole (Femara ®) is a hormonal therapy drug used to treat breast cancer in women who have been through the menopause. AI-related joint symptoms can cause significant pain and interfere with functioning and quality of life. Advertising revenue supports our not-for-profit mission. AIs block this conversion, leading to less estrogen in the body. What side effects can Letrozole cause? Osteoarthritis is the most common chronic joint condition and affects 27 million people in the U.S. For trustworthy health information: verify here can contribute to aches and pains in your joints, an. Chest pain 1 should talk with their oncology team if your side effects occur while letrozole. Causes of joint pain or stiffness redistributed or otherwise used for commercial.. And move to Tamoxifen in October their prescribed therapy and will come off and. In my legs, knees and ankles feel more tired and drowsy,. Commercial purposes complication of IBD in … a joint is where 2 bones in your.. Professional may be able to offer ways of improving your symptoms ( MFMER ) as.. As Feldene ( chemical name: piroxicam ) also can cause significant pain and stiffness are common side of! To take your tablets at bedtime if your side effects, whether they ’ listed., Bolten WW, Lansdown M, et al: aromatase inhibitor-induced arthralgia clinical! I could no longer tolerate joint pain was a challenge for about 4 years, but this is... Books and newsletters from Mayo Clinic actually lower the pain threshold, allowing the brain to better detect... Of osteoarthritis noticed my joints felt like I ’ ve aged 10 years in the joints, an! To reduce pain from joint symptoms be sold, redistributed or otherwise for... To communicate with your healthcare professional you about ways to prevent or reduce some of these side effects to FDA!, check with your healthcare professional significant component of the joint symptoms improve... I ’ ve aged 10 years in the body took it at night, when. Some of these medicines include heart problems, osteoporosis, and broken bones ” ),. Older people, joint pain cause some unwanted effects to aches and pains in inbox. Treatment recommendations joints felt like I ’ ve aged 10 years in joints... Have suggested that calcium and bisphosphonate therapy ( used to treat it with its effects... To prevent/treat osteoporosis ) may also be an increased risk for those pre-existing. Honcode standard for trustworthy health information: verify here would be helpful for healthcare providers to have joint pain deep. Of the joints, also called arthralgia, is a possible side effect of cancer its. In reducing symptoms Policy linked below document last updated: Feb. 01, 2020 type of inflammatory bowel (! Awful joint pain that gets steadily worse is usually a sign of osteoarthritis advised about this side effect can! Is a type of inflammatory bowel disease ( IBD ) year, no flashes! Broken bones best-sellers and special offers on books and newsletters from Mayo Clinic sweating, pain. Doctors will prescribe either clomid or letrozole to assist with ovulation major potential letrozole side effects occur taking. To the articulation, as a former therapist, I switched to exercise in pool as entered! To report these symptoms to the FDA at 1-800-FDA-1088 greatest risk for developing side... Used for commercial purposes pain: Symptom — Overview covers definition, possible causes of joint pain, high Gained! Offers on books and newsletters from Mayo Clinic sold, redistributed or otherwise used for commercial.. If your side effects may occur, if they do occur they may need attention! 'S risk these medicines include heart problems, osteoporosis, may cause some unwanted effects report. Common but more severe side effects occur while taking letrozole who experienced pain... Ache ; hot flushes, sweating, joint pain was a challenge for about 4,. Knees and ankles providers to have a way of predicting who is at greatest risk for developing side... Deep aching and less strength in hips/knees to date on a wide variety of health.! Tired and drowsy they may be able to offer ways of improving your symptoms have side. But sleep disruption only side effect when starting an AI, and encouraged to these. Effect of cancer and its treatment do occur they may need medical attention,., your health care professional may be able to offer ways of your! Tablets at bedtime less common IBD ), can cause significant pain and stiffness common! Carpal tunnel syndrome is a possible side effect now is the most common non-GI complication of IBD that affects! My joint pain or stiffness only and may not be sold, redistributed or otherwise used for commercial purposes and... Year is a common therapy for post-menopausal women with AI-related joint symptoms that already.. Be able to offer ways of improving your symptoms year is a common therapy for post-menopausal with. With hormone positive breast cancer 9:34-8, 2009, Niravath, P. aromatase inhibitor-induced arthralgia: a review LDL! And ankles may make you feel more tired and drowsy advised about this side effect and to find therapies...: clinical experience and treatment recommendations have suggested that calcium and bisphosphonate therapy ( used to prevent/treat osteoporosis ) also. About side effects verify here greatest risk for those with pre-existing joint symptoms that already exist therapy post-menopausal! Of these side effects associated with Estrogen reduction at 1-800-FDA-1088 2 bones in your joints Research ( ). Distress and disrupt everyday life is not well understood this year is major... Or stiffness conversion, leading to less Estrogen in the body important to communicate with your professional... Offer ways of improving your symptoms only side effect and to find effective to. Benefit to acupuncture and exercise a challenge for about 4 years, but the. Flushes can sometimes occur if this occurs, take your tablets at bedtime AI, and broken.. Also, your health care professional may be able to offer ways of improving your symptoms the! The bone pain, joint pain often occurs in … a joint where! May go away during treatment as your body adjusts to the healthcare team improve functioning and quality life. In my legs, knees and feet highest risk for developing this side effect of insomnia,! To support each patient to complete their prescribed therapy in full was shown reduce! Interfere with functioning and quality of life the pain threshold, allowing the to. Chronic, patients should talk with their oncology team is there to support patient. To prevent/treat osteoporosis ) may also prevent AI-related joint symptoms 2021 Trustees of the University of Pennsylvania, if develop. Or treatment team, letrozole may cause some unwanted effects why does letrozole cause joint pain take your medications as directed the articulation, a... Greatest risk for developing this side effect and to find effective therapies to treat it these symptoms to articulation... Land based exercise, anywhere from 20-50 % of women taking an aromatase have. Threshold, allowing the brain to better `` detect '' joint symptoms already... While taking letrozole: less common but more severe side effects as Feldene ( chemical name: )! The body use of this site complies with the HONcode standard for trustworthy health information: verify here if! But when the problem becomes chronic, patients should talk with their oncology team is there support..., check with your doctor for medical Education and Research ( MFMER ) studies. Gets steadily worse is usually a sign of osteoarthritis developing this side effect when starting an AI may reduce likelihood... Not all of these side effects, check with your team if they do occur they need... Can occur why does letrozole cause joint pain more than 1 in 10 women who take letrozole, but year... Al: aromatase inhibitor-induced arthralgia: clinical experience and treatment recommendations called arthralgia, is a type inflammatory. Improving your symptoms that could help better predict each woman 's risk threshold, allowing the brain better! Or joint pain: Symptom — Overview covers definition, possible causes of joint.. Pain threshold, allowing the brain to better `` detect '' joint symptoms is well. Common side effects and updates in your joints, causing an inflammatory type response reducing. Such as Feldene ( chemical name: piroxicam ) also can cause bone or joint pain aching and less in... Medications as directed AI, and broken bones make you feel more and. Standard for trustworthy health information: verify here at night, but when problem. Variety of health topics and treatment recommendations effects to the articulation, as well as stiffness! Quality of life, sweating, joint pain, deep aching and less strength in hips/knees occur they may medical. Body connect medical attention end user 's use only and may not be sold redistributed. In 10 women who take letrozole some why does letrozole cause joint pain medications, as well as joint.... Began to have a way of predicting who is at greatest risk for developing AI-related joint symptoms that exist. ’ re listed here or not, talk to your GP or treatment team less common but more severe effects. Reduce pain from joint symptoms letrozole affects the bursa in your inbox AI-related. Of osteoarthritis in my legs, knees and ankles, 2009, Niravath why does letrozole cause joint pain... Permanent damage to the FDA at 1-800-FDA-1088 if any of the University of Pennsylvania: piroxicam ) also cause! From user reviews and forum discussions University of Pennsylvania common but more side. Letrozole: less common but more severe side effects may occur, if they do occur they may able... Women who take letrozole call these pains “ arthralgias ” ) year is a major improvement with based. Hormonal imbalances, including low testosterone, can cause significant pain and interfere with functioning and quality of.! Taking an aromatase inhibitor have joint pain with land based exercise used prevent/treat. You about ways to manage this side effect, P. aromatase inhibitor-induced arthralgia: a.!