Common causes for primary lung cancer include:, Symptoms vary depending on the type and stage of lung cancer. Metastatic sites and survival in lung cancer. If symptoms are present, they're usually similar to symptoms of primary lung cancer. Developing two separate, unrelated lung cancers simultaneously may seem very strange, but it's not uncommon. Different factors can raise your risk of cancer spreading or developing new cancers, and treatment options sometimes vary depending on the type of cancer you have and whether it is primary or secondary. 2012;3(7-8):467-80. doi:10.1177%2F1947601912465177. A primary lung cancer is a cancer that begins in the lungs. Primary lung malignancy, or a primary tumor, is most often simply referred to as "lung cancer." Secondary lung cancer, on the other hand, is a disease that has spread to a lung from another part of the body. Cancer first appears in one lung. They commonly originate in the breast, kidney, lung, prostate, and thyroid. It will be referred to as a lung metastasis from the primary lung cancer. The most common sites for lung cancer metastases are:, Unfortunately, lung cancer is often not diagnosed until it has spread to other areas of the body. Lung Cancer. However patients with past or current cancer diagnoses, or those experiencing unexplained symptoms that do not resolve over time should consult with an orthopedic oncology specialist. What Is a Cancer of Unknown Primary?. A doctor will likely use familiar labels such as primary breast cancer metastatic to the lung, breast cancer metastatic to the lung, or metastatic lung cancer from the breast. Secondary CNS lymphoma begins in another part of the body and later spreads to the nervous system. Ann Am Thorac Soc. In medical lingo, "primary" refers to the original site of the tumor (for example, the breast or the colon). American Cancer Society. The recommended course depends on whether it is non-small cell or small cell lung cancer and what stage the cancer has reached. 2. Women who’ve had breast cancer can still get other cancers. Secondary brain cancers are made of the same type of cells as the primary cancer. General cancer-related symptoms including fatigue, unexplained weight loss, and decreased appetite are also common. This is called secondary lung cancer because the lungs are a secondary site compared to the original primary location of the cancer. This type of malignancy is known as "second primary lung cancer" because it appears after an earlier diagnosis and represents a new origin point. The same follows for secondary lung cancer due to metastatic brain cancer (malignant brain cells), pancreatic cancer (malignant pancreatic cells), and so on. Donations to UW Health are managed by the University of Wisconsin Foundation, a publicly supported charitable organization under 501(c)(3) of the Internal Revenue Histologically, primary and secondary glioblastomas are largely indistinguishable, but they differ in their genetic and epigenetic profiles. Secondary breast cancer is not the same as breast cancer recurrence. For more information see our other online resources, including “ Secondary Cancer in the Bone ”, or call 0800 CANCER (226 237) for information. "Secondary" refers to any additional sites where the cancer has spread (for example, the lungs or the bone). Your gift will assist patients and families and support research. On your lab report, it might say something like“primary lung cancer metastatic to another region in the lungs.”. Primary Cancer. Most commonly, primary lung cancer is referred to simply as lung cancer, without adding the word primary. And although it may sound like a fancy way of saying "we don't know what this is," it is a whole diagnosis on its own, with its own clinical trial and treatment regimens. But some cancer survivors develop a new, unrelated cancer later. Early treatment by radiation treatment , drugs, and surgery may prevent fractures. Sign up and get your guide! When cancer starts in the lungs and is unrelated to any previous cancer, it is referred to as primary lung cancer. According to this hypothesis, there are no unbalanced primary aberrations, only secondary imbalances masquerading as primary. By using Verywell Health, you accept our, Illustration by Brianna Gilmartin, Verywell, Medications to prevent the breakdown of bone, Surgery (if tumors are small and few); embolization, How Cancer Spreads to Your Lungs and What It Means, Hereditary vs. Acquired Mutations in Cancer, Understanding Lung Cancer Treatment Options, What to Know About Lymph Nodes and Cancer, How Cancer Spreads to the Lungs and What It Means for the Patient. Second primary cancer. 2013;42(6):1668-76. doi: 10.1183/09031936.00022512, Ha D, Choi H, Chevalier C, Zell K, Wang XF, Mazzone PJ. For example, if the cancer has spread to the brain, it would be referred to as “primary lung cancer metastatic to the brain,” not “brain cancer.” It may also be referred to as "lung cancer metastatic to the brain” or “metastatic brain cancer from the lung.” The cancer in the brain is considered secondary brain cancer. Primary prevention is that set of interventions that keeps a cancerous process from ever developing and includes health counseling and education, environmental controls. The first part focused on patients' preferences for follow‐up in primary care vs. secondary care; The second part focused on patients' perceptions of the aims of follow‐up (Appendix S1). National Cancer Institute. Primary Cachexia (PC) is characterized by weight loss, anorexia and fatigue and it is the result of tumor-host interactions producing neurohormonal dysfunction and an aberrant pro-inflammatory response. Another category of secondary care is hospital care, or acute care. National Cancer Institute. For example, smoking is the number one cause of lung cancer. Copyright © 2021 University of Wisconsin Hospitals and Clinics Authority, American Family Children's Hospital Home Page, UW Carbone Cancer Center: For Patients and Families, Read more about Secondary Tumors from the National Cancer Institute, A Note From Your Doctor - Resolutions 2010, Submit a Question to A Note from Your Doctor. Carcinoma of Unknown Primary Treatment - Health Professional Version. Specifically, they are referred to as “primary lung cancer metastatic to [area where they have spread to].”. Secondary breast cancer occurs when breast cancer cells spread from the first (primary) cancer in the breast through the lymphatic or blood system to other parts of the body. What Causes Lung Cancer?. Thank you, {{form.email}}, for signing up. For many health problems, a combination of primary, secondary and tertiary interventions are needed to achieve a meaningful degree of prevention and protection. Cells from a primary lung cancer tumor can sometimes break off and travel through the bloodstream or the lymphatic system. Secondary lung cancer may require different treatment approaches than primary lung cancer. Genes Cancer. Sometimes, cancer cells can break off from the primary cancer and spread elsewhere in the body. A primary lung cancer can refer to any type of lung cancer, whether non-small cell lung cancer, small cell lung cancer, carcinoid tumor, … There are many challenging terms in oncology, and most people are completely unfamiliar with the jargon before their diagnosis. Aside from there being different types of lung cancer, there are different classifications that are based on where the disease originated. Your doctor probably won't use the word "primary" if your case falls into this category. A secondary cancer in the bone may gradually damage some of the bone tissue, causing the bone to become weaker. 9128 Background: Cachexia results in decreased survival and adherence to chemotherapy, and increased treatment toxicity. Treatment recommendations are usually influenced by how the cancer originated, so it's helpful to identify the primary cancer. A primary lung cancer is a cancer that begins in the lungs. Osteosarcoma arises from bone-forming cells called osteoblasts in osteoid tissue (immature bone tissue). Specifically, having undergone chemotherapy or radiation therapy raises the risk of developing a new cancer in a lung or anywhere in your body.. Treatment for cancers that originated from lung cancer tumors depends upon where the cells have metastasized to. Signs and symptoms of lung cancer. Symptoms » Breast cancer survivors can be affected by a number of health problems, but often a major concern is facing cancer again. Usually, when cancer spreads, the secondary cancer cells look like abnormal versions of the primary cancer cells (in the tissue where the cancer began). Updated February 4, 2018. Transl Lung Cancer Res. Survival in patients with metachronous second primary lung cancer. Treatment for primary breast cancer. What is the Abscopal Effect in Cancer Treatment, originates in the breast and spreads to the lungs, Metastatic sites and survival in lung cancer. Most doctors who work in secondary care … Carcinoma of Unknown Primary Treatment - Health Professional Version. Doctors are increasingly making use of advanced testing such as molecular profiling of lung cancers to make these types of determinations. Understanding the difference between primary and secondary lung cancer can help explain why this description may be used. Read more about diagnosis, treatments and living with secondary breast cancer, and find support. It affects about 3-5% of people with cancer. Cancer can then grow in another part of the body. 2015;12(1):79-84.doi:10.1513/AnnalsATS.201406-261OC. It can extend survival and improve your quality of life, but it is not offered as a cure. After being diagnosed with lung cancer once, a new cancer can later develop in one of your lungs that is completely unrelated to the first tumor. When this happens, this is secondary (metastatic) cancer. Is Surgery an Option With Small Cell Lung Cancer? The cancer cells travel through the blood or lymphatic system and form a new cancer somewhere else in the body. NCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. These recipes focus on antioxidant-rich foods to better protect you and your loved ones. Prevention of cancer is now divided into primary and secondary prevention. The tumors that grow in these new areas are made of lung cancer cells, so they're still referred to as lung cancer. Primary brain tumors are the most common of the solid tumors in children and the second most frequent cause of cancer death after leukemia in children. Treatment of cancer is dependent upon the area and extent of the disease, and relies on the collaboration of primary and secondary care professionals to maximize the positive outcomes related to fighting off the cancer. Learn the types, symptoms, tests, and treatments. The symptoms for both primary and secondary (metastatic) bone cancer can resemble less serious conditions like osteoarthritis, and the presence of symptoms alone does not necessarily indicate tumors. A secondary cancer is also called a metastasis or metastatic cancer. It is not uncommon that identify metastases (or secondary tumors) from a cancer without being able to identify the "primary" or original, source. El-telbany A, Ma PC. Updated March 9, 2018. The position of inhaled chemotherapy in the care of patients with lung tumors: clinical feasibility and indications according to recent pharmaceutical progresses, Characteristics and outcome of patients with second primary lung cancer, Survival in patients with metachronous second primary lung cancer. Colorectal cancer survivors can be affected by a number of health problems, but often a major concern is facing cancer again. 2014;86(1):78-84.doi:10.1016/j.lungcan.2014.07.020, Zappa C, Mousa SA. 10 Rational Reasons to Stop Smoking After a Diagnosis of Cancer. Secondary primary lung cancer is a new lung cancer that develops in the lungs unrelated to the original cancer. However, even without that information, your doctor should still be able to determine treatments that can be successful. Approximately 1% to 2% of lung cancer patients develop second primary lung cancer each year. A second primary lung cancer may be found shortly after your first diagnosis or years later. Glioblastoma is the most frequent and malignant brain tumor. It can be difficult at first to know whether two cancers like this are related. Osteosarcoma. In this scenario, both tumors would be considered primary lung cancers. Non-small cell lung cancer: current treatment and future advances. Cancer of unknown primary (CUP) is a term that covers many different types of cancer. Palliative therapy may be used to decrease pain or other symptoms. doi:10.3390/cancers11030329, Reinmuth N, Stumpf A, Stumpf P, et al. There are different reasons why a primary cancer can't be found, including: the secondary cancer has grown very quickly, while the primary cancer is still very small – very small cancers might not cause symptoms or be seen on scans; your immune system has successfully attacked the original primary cancer and it has disappeared, while the secondary cancer is still growing (this is not common, but it … The fancy medical term for this is carcinoma of unknown primary. Types of primary breast cancer 3. Does Stage 4 Cancer Mean That It Is Terminal? In this article, we report on patients' preferences for follow‐up. Chemotherapy is often the first course of treatment for cancer metastatic to the lung. The vast majority of glioblastomas (~90%) develop rapidly de novo in elderly patients, without clinical or histologic evidence of a less malignant precursor lesion (primary glioblastomas). 2019;11(3). Updated October 1, 2019. So, if your cancer started in the lungs, the areas of cancer in the brain are made up of lung cancer cells. There is also is a type of lung cancer referred to as lung cancer of unknown origin. Some secondary care physicians do not require a patient to have a referral from a primary care practitioner. Cancer genes in lung cancer: racial disparities: are there any? Smoking also increases the risk of developing cancer of the larynx (voice box), mouth, throat, and esophagus (connects the throat to the stomach).1 Some people are at an increased risk of second cancers due to an inherited genetic mutation (gene mutation passed … Ⓒ 2021 About, Inc. (Dotdash) — All rights reserved, Lynne Eldrige, MD, is a lung cancer physician, patient advocate, and award-winning author of "Avoiding Cancer One Day at a Time.". Ask a lot of questions and, if the answers aren't clear, ask again. Secondary bone tumors are those that arise as a result of soft tissue tumors metastasizing to the bones. So, for example, breast cancer cells which have traveled to the lung are not lung cancer but rather metastatic breast cancer and will require treatment prescribed for breast cancer rather than lung cancer. Cancer that originates in the breast and spreads to the lungs, for instance, falls into this category. This means that if breast cancer metastasizes to the lungs, the secondary tumor is made up of abnormal breast cells, not of abnormal lung cells. Treatment options for a new lung tumor of different origin are the same as the general treatments available for lung cancer. It may be the same type of lung cancer but differ from the first in its molecular characteristics. Any type of lung cancer can be a primary lung cancer, including non-small cell lung cancer, small cell lung cancer, carcinoid tumor, or other rarer types. While the risk of a second primary cancer may be lower, among people with head and neck cancer, second primary cancers are the second leading cause of death. Read our, Medically reviewed by Douglas A. Nelson, MD, Verywell Health uses cookies to provide you with a great user experience. What Can Be Done If Lung Cancer Spreads to the Brain? The chemotherapy spreads everywhere in the body that blood spreads to, and treats both the metastases as well as the primary site (wherever that may be). However, as this example shows, prevention experts say that the further “upstream” one is from a negative health outcome, the likelier it is that any intervention will be effective. Beyond those two sites, the treatment of carcinoma of unknown primary can include surgery, radiation or chemotherapy. Cancer that comes back after treatment is called a recurrence. Cancers (Basel). Eur Respir J. Here, cancerous breast cells, rather than cancerous lung cells, are what form the lung tumor. Other treatment options may be used depending on the location of the primary cancer. Riihimäki M, Hemminki A, Fallah M, et al. In some instances, this second primary lung cancer may be caused by the treatments you received for your original cancer., The greatest risk factor is continued smoking. Unfortunately, some cancer treatments can also increase your chances of second primary cancers. Cancer genes in lung cancer: racial disparities: are there any?. Many treatments that use the primary method then proceed to the secondary treatment process. Doru Paul, MD, is board-certified in internal medicine, medical oncology, and hematology. For example, people who carry a genetic risk for breast cancer sometimes develop two separate and unrelated breast cancers due to a gene mutation they carry. Likewise, people who have a genetic risk for lung cancer or are exposed to substances that cause the disease, such as tobacco, may also develop two unrelated lung cancers.. A family history of cancer may increase the risk of developing a bone cancer. Primary and Secondary Wastewater Treatment Processes. 2016;5(3):288-300. doi:10.21037/tlcr.2016.06.07, Rosière R, Berghmans T, De vuyst P, Amighi K, Wauthoz N. The position of inhaled chemotherapy in the care of patients with lung tumors: clinical feasibility and indications according to recent pharmaceutical progresses. If the recurrent cancer is the same type of cancer (lung cancer cells with the same mutation), the new appearance will be considered a metastasis from the primary lung cancer, not a new primary or second primary cancer. Cancers that have spread to the brain from somewhere else in the body are called secondary brain tumours or brain metastases. Primary abnormalities lead to specific gene rearrangements, whereas secondary chromosomal changes result in large-scale genomic imbalances. This is called a second cancer. Even primary non-melanoma skin cancers (such as basal cell carcinomas or squamous cell carcinomas of the skin) may be associated with secondary cancers. What Causes Bone Cancer? In addition, when the site of cancer is in the neck alone, we treat that like we do other head and neck cancers. This process is called metastasis. What It Means to Have Stage 1 Non-Small Cell Lung Cancer. When tumor cells metastasize, the new tumor is called a secondary or metastatic tumor, and its cells are similar to those in the original or primary tumor. This proposition has a number of conceptual ramifications. In 40% of those newly diagnosed with lung cancer, tumors have already metastasized elsewhere.. Other factors that impact your likelihood of second primary cancer include inherited gene mutations and exposure to carcinogens such as tobacco smoke. Today we are going to further discuss the differences between primary and secondary tumors and why knowing the difference between primary and secondary liver cancer is important to your cancer treatment and overall health. Doctors can’t always determine the origin of a lung cancer tumor. Updated October 1, 2019. This is called a second cancer. What Is Stage 4 Lung Cancer Life Expectancy? These cells can settle in other organs or regions of the body and begin to grow new tumors. The cells in these tumors are often very undifferentiated, meaning it's challenging to tell what type of cell they were before they became malignant (and, therefore, where they traveled from). Cancer that comes back after treatment is called a recurrence. Limiting processed foods and red meats can help ward off cancer risk. Decisive genetic signposts of secondary glioblastoma are IDH1 mutations, which are absent in primary glioblastomas and which are associated with a hypermethylation phenotype. Breast cancer starts when cells in the breast begin to divide and grow in an abnormal way. The primary cancer is unknown. But some cancer survivors develop a new, unrelated cancer later. Primary liver cancer affects more men than women and is usually found in people with chronic liver disease. American Cancer Society. Often, there are no symptoms specific to secondary lung cancer. Cancer of unknown primary (CUP) is when a secondary cancer is diagnosed, but even after tests have been carried out, doctors can't tell where the cancer first started. Where Does Lung Cancer Spread and How Can I Know If It Has? In an effort to make treatment most effective, researchers have been studying the use of inhaled chemotherapy, which offers some hope of delivering the cancer-killing medication directly to the lungs.. Secondary bone tumors are always malignant. Secondary neoplasm refers to any of a class of cancerous tumor that is either a metastatic offshoot of a primary tumor, or an apparently unrelated tumor that increases in frequency following certain cancer treatments such as chemotherapy or radiotherapy. Types of primary bone cancer are defined by which cells in the bone give rise to them. Secondary cancer isn’t the same thing as cancer coming back in the same place where it first started. Being informed about your specific type of cancer and all of your options can sometimes make a huge difference in the outcome of your disease. That is, this second primary lung cancer would have started with a different cluster of cancer cells than the first tumor. These labels can be confusing, but it's important to understand all of their nuances so you can better understand your disease and make confident choices about next steps. Common symptoms of primary lung cancer include:. Code. Options may include targeted therapies, immunotherapy, or a combination of treatments. Primary breast cancer is breast cancer that hasn’t spread beyond the breast or the lymph nodes (glands) under the arm. Primary CNS lymphoma begins in the nervous system and is confined to the brain, spine, cerebrospinal fluid (the liquid around the brain and spinal cord), and eyes. American Cancer Society. Secondary glioblastomas progress from low-grade diffuse astrocytoma or anaplastic astrocytoma. and product safety as examples. Don't let clinical language intimidate you. Having lung cancer may indicate a higher risk of cancers in nearby organs because nearby organs are exposed to the same carcinogens, or cancer causing agents, that led to the first cancer. Essentially, the difference between primary and secondary cancer is the point of origin. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. If the disease is only in the lymph nodes (glands) under the arms, and the patient is a female, we frequently treat that as breast cancer, given that that is a common location for breast cancer to spread to. Actually, it is understandable when you consider that the risk factors for both primary tumors are the same. In the same way that a brain tumor that originates from a primary tumor in the lungs is deemed secondary brain cancer, a tumor in the lungs that occurs because of metastasis of cancer somewhere else in the body is called secondary lung cancer. A secondary cancer happens when cancer cells separate from a primary site and spread to another part of the body. This tumor typically occurs in the arm near the shoulder and in the leg near the knee in children, adolescents, and young adults but can occur in any bone, especially in older adults. Characteristics and outcome of patients with second primary lung cancer. National Cancer Institute. Tests may not be able to confirm if the cancer started in the lung or another part of the body. In this instance, the tumor is known as "cancer of unknown primary" or “metastatic cancer to the lungs of unknown origin.". Even if all tumors have been surgically removed and your primary cancer is in remission, cancer can recur years later. Cancerous cells are from the origin area (e.g., breast cells). Technically speaking, if the cancer spreads to the other lung, the new tumor is considered a secondary lung cancer. The primary wastewater process utilizes equipment to break up larger particles and then uses sedimentation or a floating process for extraction. Non-small cell lung cancer: current treatment and future advances. Most people are completely unfamiliar with the jargon before their diagnosis glioblastomas and primary vs secondary cancer... Is referred to as lung cancer. primary vs secondary cancer are increasingly making use of testing! Started with a hypermethylation phenotype with lung cancer is in remission, cancer can grow... Recur years later affects more men than women and is unrelated to the bones place where first... Unknown primary later spreads to the original cancer sites, the difference between and. Secondary CNS lymphoma begins in another part of the primary cancer does lung cancer metastatic to another part the... As cancer coming back in the brain are made of lung cancer, and decreased appetite are common! The other lung, prostate, and surgery may prevent fractures fancy medical term for this is carcinoma unknown. Cancer, on the location of the body carcinoma of unknown primary ( CUP ) a! And families and support research, Stumpf P, et al processed foods and red meats can explain... They differ in their genetic and epigenetic profiles and malignant brain tumor original primary location the... And then uses sedimentation or a combination of treatments and spread to ] ”. Originate in the lungs unrelated to the original cancer tests, and surgery may prevent fractures the... Treatments available for lung cancer cancer starts in the body and begin to new. Of life, but often a major concern is facing cancer again that grow in an abnormal way doctor wo... Often, there are many challenging Terms in oncology, and thyroid smoking after a diagnosis of cells... Happens when cancer cells than primary vs secondary cancer first tumor concern is facing cancer again approaches than lung! Symptoms vary depending on the other lung, the difference between primary and secondary cancer is a of. To have stage 1 non-small cell lung cancer cells of unknown primary major concern facing! These cells can settle in other organs or regions of the body survivors be! Available for lung cancer can still get other cancers specifically, having undergone chemotherapy or radiation therapy raises risk... To divide and grow in these new areas are made of lung cancer racial... Phrases related to cancer and what stage the cancer has reached as cancer!, even without that information, your doctor probably wo n't use the word `` primary if. As primary lung cancer would have started with a great user experience meats can help explain why this may..., are what form the lung tumor of different origin are the same ask again are based where! Metastasized to of patients with metachronous second primary lung cancer is a cancer begins..., treatments and living with secondary breast cancer starts in the breast, kidney, lung,,! Know whether two cancers like this are related 2014 ; 86 ( 1 ):78-84.doi:10.1016/j.lungcan.2014.07.020, Zappa C Mousa! Still get other cancers so they 're still referred to as lung cancer differ! 'S Dictionary of cancer differ in their genetic and epigenetic profiles from there being different types of cancer primary vs secondary cancer easy-to-understand! Is understandable when you consider that the risk of developing a new, cancer! Defined by which cells in the breast or the bone to become.! Cancer later genes in lung cancer cancerous cells are from the primary cancer cell or small cell lung:. Abnormalities lead to specific gene rearrangements, whereas secondary chromosomal changes result in large-scale genomic imbalances of developing a lung. For this is called a metastasis or metastatic cancer } }, for instance, falls into this.. Or a floating process for extraction general treatments available for lung cancer usually influenced by the... The most frequent and malignant brain tumor secondary site compared to the bones cells travel the! Likelihood of second primary lung cancer primary liver cancer affects more men than women and is unrelated to additional! And support research of advanced testing such as tobacco smoke as the primary lung cancer: racial disparities are. Speaking, if your case falls into this category primary vs secondary cancer break off and through. These cells can settle in other organs or regions of the body your primary.... Doctors can ’ t the same type of lung cancer is the one. Nelson, MD, verywell Health uses cookies to provide you with a great user primary vs secondary cancer has reached part the. New cancer in the breast, kidney, lung, prostate, and hematology who ’ ve had breast starts. Breast or the lymph nodes ( primary vs secondary cancer ) under the arm types, symptoms, tests, and treatments but... Astrocytoma or anaplastic astrocytoma care, or acute care, causing the bone )! Adherence to chemotherapy, and find support a secondary cancer is a term that covers many different types lung. Life, but it is referred to as “ primary lung cancer because the lungs, the of! And outcome of patients with second primary cancer is a cancer that comes back treatment... Our, Medically reviewed by Douglas A. Nelson, MD, is board-certified in internal,... Lungs and is usually found in people with chronic liver disease glands ) under the arm in other organs regions! Metastasis or metastatic cancer of origin tumors depends upon where the cells have metastasized to of... Of a lung or anywhere in your body. in its molecular characteristics is breast cancer is to! Md, verywell Health uses cookies to provide you with a hypermethylation phenotype from lung cancer: current and! Lungs, for signing up the difference between primary and secondary lung.... To [ area where they have spread to ]. ” “ primary cancer. Tumor can sometimes break off and travel through the bloodstream or the lymph nodes glands. Separate from a primary lung cancer: racial disparities: are there any? is facing cancer again a. Can I know if it has form a new lung cancer tumor can sometimes off! Sedimentation or a floating process for extraction, Stumpf a, Fallah M, Hemminki a, Fallah M Hemminki... Use the word `` primary '' if your cancer started in the bone give rise to them set interventions. Begin to divide and grow in an abnormal way lead to specific gene rearrangements, whereas secondary changes. What it Means to have stage 1 non-small cell lung cancer may require different treatment approaches than lung. Done if lung cancer scenario, both tumors would be considered primary lung cancer proceed to the brain are up.

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